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recombinant mouse interleukin il 1β  (R&D Systems)


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    R&D Systems recombinant mouse interleukin il 1β
    Recombinant Mouse Interleukin Il 1β, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 229 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+mouse+interleukin+il+1%CE%B2/Recombinant+Mouse+IL-1+beta%2FIL-1F2+Protein/pm41881976-247-0-7
    Average 96 stars, based on 229 article reviews
    recombinant mouse interleukin il 1β - by Bioz Stars, 2026-09
    96/100 stars

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    Recombinant:

    Article Title: Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis.
    Article Snippet: .. Recombinant mouse interleukin (IL)-1β was obtained from R&D Systems (#401-ML-010, Minneapolis, USA). .. TEPP-46 (#S7302) and DASA-58 (#S7928) were purchased from Selleck Chemicals (Houston, TX, USA).

    Article Title: Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis
    Article Snippet: .. Recombinant mouse interleukin (IL)-1β was obtained from R&D Systems (#401-ML-010, Minneapolis, USA). .. TEPP-46 (#S7302) and DASA-58 (#S7928) were purchased from Selleck Chemicals (Houston, TX, USA).

    Article Title: Pentraxin 3 regulates neutrophil infiltration to the brain during neuroinflammation
    Article Snippet: .. Briefly, 1 x 10 5 cells/well of bEnd5 cells were seeded onto Transwell inserts (6.5 mm with 3.0 μm pore polycarbonate membrane (Sigma-Aldrich, UK)) for 24 h. bEnd5 cells were then pre-treated with recombinant mouse interleukin (IL)-1β (100 ng/ml) (R&D Systems, UK) or vehicle (low 0.1% endotoxin bovine serum albumin (BSA) in NaCl) for 4 h. Subsequently, 2 x 10 5 neutrophils isolated from WT or PTX3 KO mice were added to the luminal (top) compartment of vehicle (WT neutrophils) or IL-1β (WT or PTX3 KO neutrophils) treated inserts and allowed to transmigrate for 24 h. Neutrophils were collected from the abluminal compartments, centrifuged at 400 g for 10 min and counted with a hemocytometer. ..

    Article Title: Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.
    Article Snippet: .. At approximately tmax (1 h post SMI gavage), animals received an intravenous injection of 300 ng of recombinant mouse interleukin (IL)-1β (R&D Systems, Minneapolis, MN) and 100 ng of recombinant mouse IL-23 (generated at Genentech). ..

    Membrane:

    Article Title: Pentraxin 3 regulates neutrophil infiltration to the brain during neuroinflammation
    Article Snippet: .. Briefly, 1 x 10 5 cells/well of bEnd5 cells were seeded onto Transwell inserts (6.5 mm with 3.0 μm pore polycarbonate membrane (Sigma-Aldrich, UK)) for 24 h. bEnd5 cells were then pre-treated with recombinant mouse interleukin (IL)-1β (100 ng/ml) (R&D Systems, UK) or vehicle (low 0.1% endotoxin bovine serum albumin (BSA) in NaCl) for 4 h. Subsequently, 2 x 10 5 neutrophils isolated from WT or PTX3 KO mice were added to the luminal (top) compartment of vehicle (WT neutrophils) or IL-1β (WT or PTX3 KO neutrophils) treated inserts and allowed to transmigrate for 24 h. Neutrophils were collected from the abluminal compartments, centrifuged at 400 g for 10 min and counted with a hemocytometer. ..

    Isolation:

    Article Title: Pentraxin 3 regulates neutrophil infiltration to the brain during neuroinflammation
    Article Snippet: .. Briefly, 1 x 10 5 cells/well of bEnd5 cells were seeded onto Transwell inserts (6.5 mm with 3.0 μm pore polycarbonate membrane (Sigma-Aldrich, UK)) for 24 h. bEnd5 cells were then pre-treated with recombinant mouse interleukin (IL)-1β (100 ng/ml) (R&D Systems, UK) or vehicle (low 0.1% endotoxin bovine serum albumin (BSA) in NaCl) for 4 h. Subsequently, 2 x 10 5 neutrophils isolated from WT or PTX3 KO mice were added to the luminal (top) compartment of vehicle (WT neutrophils) or IL-1β (WT or PTX3 KO neutrophils) treated inserts and allowed to transmigrate for 24 h. Neutrophils were collected from the abluminal compartments, centrifuged at 400 g for 10 min and counted with a hemocytometer. ..

    Injection:

    Article Title: Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.
    Article Snippet: .. At approximately tmax (1 h post SMI gavage), animals received an intravenous injection of 300 ng of recombinant mouse interleukin (IL)-1β (R&D Systems, Minneapolis, MN) and 100 ng of recombinant mouse IL-23 (generated at Genentech). ..

    Generated:

    Article Title: Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.
    Article Snippet: .. At approximately tmax (1 h post SMI gavage), animals received an intravenous injection of 300 ng of recombinant mouse interleukin (IL)-1β (R&D Systems, Minneapolis, MN) and 100 ng of recombinant mouse IL-23 (generated at Genentech). ..



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    Verification of the therapeutic effect of PM in delaying the senescence of chondrocytes. (a) Schematic diagram of primary chondrocyte isolation and in vitro experimental design. (b) Representative images of brightfield, Alcian blue, Safranin O, and Toluidine blue staining of chondrocytes. (c, d) Protein levels of p16 and SLPI detected by Western blot (WB) <t>after</t> <t>IL-1β</t> treatment (c) or Slpi overexpression (OE-Slpi; d). (e, f) Representative images of SA-β-gal staining (e) and quantitative analysis of positive cells (f) in OE-negative control (OE-NC) or OE-Slpi chondrocytes. (g, h) Representative images of SA-β-gal staining (g) and quantitative analysis of positive cells (h) in chondrocytes treated with 10 ng/ml IL-1β alone or combined with 1 μM PM. (i, j) Quantitative real-time PCR (qPCR) analysis of p16 and MMP3 mRNA expression in chondrocytes treated with 10 ng/ml IL-1β alone or combined with 1 μM PM. (k, l) Representative images of SA-β-gal staining (k) and quantitative analysis of positive cells (l) in chondrocytes treated with H₂O₂ alone or combined with 1 μM PM. (m, n) qPCR analysis of p16 and MMP3 mRNA expression in chondrocytes treated with H₂O₂ alone or combined with 1 μM PM. Data are presented as mean ± standard deviation (n = 3 independent experiments). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant. (Student’s t -test: f; ANOVA: h, i, j, l, m, n). OE, overexpression; NC, negative control.
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    Verification of the therapeutic effect of PM in delaying the senescence of chondrocytes. (a) Schematic diagram of primary chondrocyte isolation and in vitro experimental design. (b) Representative images of brightfield, Alcian blue, Safranin O, and Toluidine blue staining of chondrocytes. (c, d) Protein levels of p16 and SLPI detected by Western blot (WB) <t>after</t> <t>IL-1β</t> treatment (c) or Slpi overexpression (OE-Slpi; d). (e, f) Representative images of SA-β-gal staining (e) and quantitative analysis of positive cells (f) in OE-negative control (OE-NC) or OE-Slpi chondrocytes. (g, h) Representative images of SA-β-gal staining (g) and quantitative analysis of positive cells (h) in chondrocytes treated with 10 ng/ml IL-1β alone or combined with 1 μM PM. (i, j) Quantitative real-time PCR (qPCR) analysis of p16 and MMP3 mRNA expression in chondrocytes treated with 10 ng/ml IL-1β alone or combined with 1 μM PM. (k, l) Representative images of SA-β-gal staining (k) and quantitative analysis of positive cells (l) in chondrocytes treated with H₂O₂ alone or combined with 1 μM PM. (m, n) qPCR analysis of p16 and MMP3 mRNA expression in chondrocytes treated with H₂O₂ alone or combined with 1 μM PM. Data are presented as mean ± standard deviation (n = 3 independent experiments). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant. (Student’s t -test: f; ANOVA: h, i, j, l, m, n). OE, overexpression; NC, negative control.
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    Image Search Results


    Verification of the therapeutic effect of PM in delaying the senescence of chondrocytes. (a) Schematic diagram of primary chondrocyte isolation and in vitro experimental design. (b) Representative images of brightfield, Alcian blue, Safranin O, and Toluidine blue staining of chondrocytes. (c, d) Protein levels of p16 and SLPI detected by Western blot (WB) after IL-1β treatment (c) or Slpi overexpression (OE-Slpi; d). (e, f) Representative images of SA-β-gal staining (e) and quantitative analysis of positive cells (f) in OE-negative control (OE-NC) or OE-Slpi chondrocytes. (g, h) Representative images of SA-β-gal staining (g) and quantitative analysis of positive cells (h) in chondrocytes treated with 10 ng/ml IL-1β alone or combined with 1 μM PM. (i, j) Quantitative real-time PCR (qPCR) analysis of p16 and MMP3 mRNA expression in chondrocytes treated with 10 ng/ml IL-1β alone or combined with 1 μM PM. (k, l) Representative images of SA-β-gal staining (k) and quantitative analysis of positive cells (l) in chondrocytes treated with H₂O₂ alone or combined with 1 μM PM. (m, n) qPCR analysis of p16 and MMP3 mRNA expression in chondrocytes treated with H₂O₂ alone or combined with 1 μM PM. Data are presented as mean ± standard deviation (n = 3 independent experiments). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant. (Student’s t -test: f; ANOVA: h, i, j, l, m, n). OE, overexpression; NC, negative control.

    Journal: Computational and Structural Biotechnology Journal

    Article Title: seneR: An R package for comprehensive senescence assessment and its application in type 2 diabetes and osteoarthritis

    doi: 10.1016/j.csbj.2025.12.031

    Figure Lengend Snippet: Verification of the therapeutic effect of PM in delaying the senescence of chondrocytes. (a) Schematic diagram of primary chondrocyte isolation and in vitro experimental design. (b) Representative images of brightfield, Alcian blue, Safranin O, and Toluidine blue staining of chondrocytes. (c, d) Protein levels of p16 and SLPI detected by Western blot (WB) after IL-1β treatment (c) or Slpi overexpression (OE-Slpi; d). (e, f) Representative images of SA-β-gal staining (e) and quantitative analysis of positive cells (f) in OE-negative control (OE-NC) or OE-Slpi chondrocytes. (g, h) Representative images of SA-β-gal staining (g) and quantitative analysis of positive cells (h) in chondrocytes treated with 10 ng/ml IL-1β alone or combined with 1 μM PM. (i, j) Quantitative real-time PCR (qPCR) analysis of p16 and MMP3 mRNA expression in chondrocytes treated with 10 ng/ml IL-1β alone or combined with 1 μM PM. (k, l) Representative images of SA-β-gal staining (k) and quantitative analysis of positive cells (l) in chondrocytes treated with H₂O₂ alone or combined with 1 μM PM. (m, n) qPCR analysis of p16 and MMP3 mRNA expression in chondrocytes treated with H₂O₂ alone or combined with 1 μM PM. Data are presented as mean ± standard deviation (n = 3 independent experiments). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant. (Student’s t -test: f; ANOVA: h, i, j, l, m, n). OE, overexpression; NC, negative control.

    Article Snippet: For over-expression SLPI, chondrocytes were transfected with pcDNA3.1/Slpi full-length plasmid using Lipo8000 (Beyotime) according to the manufacturer’s instructions.For IL-1β treatment, mouse primary chondrocytes were treated with recombinant mouse IL-1β (10 ng/ml, MedChemExpress) for 24 h. For H2O2-induced senescence, mouse primary chondrocytes were treated with H2O2 (200 μM, MKBio Shanghai) for 2 h. For PM treatment, mouse primary chondrocytes were treated with or without PM (MedChemExpress), dissolved in DMSO (Dimethyl sulfoxide, MedChemExpress).

    Techniques: Isolation, In Vitro, Staining, Western Blot, Over Expression, Negative Control, Real-time Polymerase Chain Reaction, Expressing, Standard Deviation